Fourth Human Parechovirus Serotype
نویسندگان
چکیده
We identified a novel human parechovirus (HPeV) type (K251176-02) from a neonate with fever. Analysis of the complete genome showed K251176-02 to be a new HPeV genotype. Since K251176-02 could not be neutralized with antibodies against known HPeV serotypes 1-3, it should be classified as a fourth HPeV serotype.
منابع مشابه
The isolation of human parechovirus 1 from cases of acute respiratory illness in children.
1. Hamada, S. and Slade, H. D. (1980): Biology, immunology and carinogenisity of Streptococcus mutans. Microbiol. Rev., 44, 331-384. 2. Okahashi, N., Sasakawa, C., Yoshikawa, M., Hamada, M. and Koga, T. (1989): Cloning of a surface protein antigen gene from serotype c StylePtOCOCCuS mutanS. Mol. Microbio1., 3, 221228. 3. Hanada, N. and Kuramitsu, H. K. (1989): isolation and characterization of ...
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